We developed a proprietary testing pipeline for nutraceuticals, vitamins, and diets. Such a pipeline enables us to obtain individual organism-level readouts of interventions using novel and cutting-edge techniques (single-cell epigenetics, physiology, and behavior testing, key metrics of metabolism and inflammation, multi-OMICS platform, and advanced machine learning). The resulting information matrix maps personalized metrics of an organism’s response to a specific intervention, namely, the effect of each intervention on the biological age of an organism. Our pipeline enables testing of large numbers of interventions in small mammals (rodents) with the output information directly applicable to humans to provide predictions and recommendations of how the same nutraceuticals, vitamins, and diets will affect individual human biological age and, more importantly, individual healthspan and lifespan.