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PureNSM specializes in creating Nano and Liposomal Formulas
We are specialists in the production and development of Liposomal and Nano-sized supplements. You can upgrade any of your current or new formulas!

  • Upgrade any solid dosage form. (capsules and tablets)
  • Enhance the value of your formula.
  • Sell supplements with greater absorption.
  • Sell an exclusive formula.

With our proprietary system you can turn any formula into an effective Liposomal Formula using our proprietary self-emulsifying drug delivery systems (SEDDS). Solid dosage forms like tablets or capsules are most effectively turned into Liposomal Formulas using the self-microemulsifying drug delivery systems (SMEDDS). This will improve the oral absorption tremendously.

Liposomal Bottle

Depending on your budget and needs, PureNSM can create two main types of Liposomal Formulas for your brand:

  • Self-Emulsifying Liposomal Delivery System (SEDDS and SMEDDS):
    *Ideal for Solid Dosages (capsules & tablets) * Economical
    Your actives are self-micro-emulsified in the stomach, creating liposomal actives.
  • Creation of Micro-Emulsion Containing Nano/Liposomes:
    *Ideal for Liquids & Solid Dosages * Full Control of Particle Size
    This is the gold standard in the creation of Nano/Liposomal delivery where the Liposomal or Nanoparticles can be measured prior to ingesting them.

This system works for both hydrophobic and water soluble actives. In this system we first create an emulsion, mix it with the actives and then send it through the HPH. Depending on the emulsion and how often we send it through the HPH we can end up with particle sizes from 50 to 1000 nanometers. We can completely control the particle sizes from below 100 nm to above 250 nm for example or a mix of a range of sizes. We write a lot about this method below. For this gold standard process we use our High-Pressure Homogenizer (HPH) IDEX M815.

Delayed and Slow Release of Actives:

  1. Slow Release of Liposomal Actives for SEDDS with delivery in the intestine in the form of tablets: Tablets can be formulated for 4-8 hours of dissolution time. This system can also work with delivery to the intestine in Delayed Release Capsules, but for quicker release once in the intestine.
  2. Delayed micro-release of Micro-Emulsion Containing Nano/Liposomes: In order to get a delayed release action out of the Nano/Liposomal actives created by the HPH, we react the microemulsion with Cyclodextrin that we then dry into cakes and subsequently mill into powder to then be encapsulated or used in our tableting. We typically also mix this with other delayed release excipients.
All our excipients can follow the “Clean Label” principals so your customers will not see unfamiliar chemically sounding names on the label.
PureNSM offers various lipids and surfactant mixtures for the creation of your proprietary SMEDDS. The exact formulation depends on the active ingredients.

SEDDS can be formulated as liquid or solid dosage forms, such as capsules or tablets. Solid SEDDS are often formulated as self-microemulsifying drug delivery systems (SMEDDS), which can be converted into microemulsions in the presence of aqueous fluids found in the stomach.

SEDDS can have several advantages over conventional oral dosage forms, including improved bioavailability and reduced variability in absorption.

Once ingested, the capsule or tablet dissolves in the stomach, and the SEDDS mixture is released. The SEDDS mixture then spontaneously emulsifies into small droplets, creating a larger surface area for the drug to dissolve in and be absorbed by the body.

Liposomal Formulas

We utilize our High-Pressure Homogenizer to deliver the best quality products for you. Our expert chemist is also available for formulation and will scale your formulation up for production. It’s an advantage to formulate and manufacture at the same facility because once the formulation is made it may not scale - and this saves you time and money.

Liposomal Active X

Take any known ingredient and upcharge it with Liposomal Actives and gain competitive advantage:

  • Increase Sales
  • Increase Appeal
  • Charge a Higher Price!

 

NanoNSM

We are specialists in the production and development of Nano-sized health and wellness products. We utilize our High-Pressure Homogenizer to deliver the best quality products for you. Our expert chemist is also available for formulation and will scale your formulation up for production. It’s an advantage to formulate and manufacture at the same facility because once the formulation is made it may not scale - and this saves you time and money.

homogenizer

Schedule a Liposomal Formulation Consultation

Our professional team is here to help you get liposomes working to your advantage. We take your concerns and goals into the picture, including your budget. We can increase both absorption and speed of absorption of your formula and help you gather medical data to prove your system works.

Cost of Liposomal Formulations

Like with everything you do in your business you need to do a cost benefit analysis prior to launching your first Liposomal Formula. We have never seen the cost be higher than the benefit of marketing a liposomal formula.

While Liposomal Formulas are more expensive, the benefits are far more enticing to your customers. This results in your advertising dollars becoming more effective whenever you use the word “LIPOSOMAL FORMULA” in your advertising and labeling.

Why Nano?

Nanoemulsions come in handy when you want to increase absorption. As a rule of thumb, a nanoemulsion is 10X more effective. Many doctors see a decline in patients when they no longer have access to nutrients delivered through an IV. They therefore often recommend Nanoemulsions. The body can absorb nanoemulsions extremely fast; the effects can sometimes be felt before you swallow! Now that’s SUPER absorption!

What are nanoemulsions, liposomes, colloids?

Liposome

Liposomes are generally defined to be 100-1000 nanometers in diameter.

Nanoemulsions

Nanoemulsions are less than 100 nanometers.

Colloid Mixture

A colloid is a mixture that has particles ranging between 1 and 1000  nanometers in diameter, yet are still able to remain evenly distributed throughout the solution. 
liposome

Is Nano Good for Business?

Yes! It makes perfect business sense to use Nanoemulsions when you are marketing high-end products that contain expensive ingredients. Besides, have you heard the term “differentiate or die”?

liposome

What is a Nano?

Nano is short for “nanometer” which is a unit prefix meaning "one billionth". Used primarily with the metric system. This prefix denotes a factor of 10^−9 or 0.000000001. It is often encountered in science and electronics for prefixing units of time and length.

nano image
nano

Smaller is Better

Our State-of-the-art Nanotechnology creates millions of particles that are so small they could fit on the head of a needle. These tiny particles go right into your bloodstream to be distributed to every cell. This means your body will quickly absorb the nutrients, often bypassing the digestive system.

Our Liposomes are Built Better! 🤔 How?

liposome

Steeper Distribution Curve

You want to provide your clients with the most reliable product. One with reliably high efficacy and potency.  You get that from a product that has nanoparticles of the same size. Particle size uniformity is important because this increases absorption and efficacy.

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nano chart
sonicator

Do not choose a Contract Manufacturer that uses ultrasonic homogenizers.

Quality is Key!

We use a high powered Microfluidizer (High Pressure Homogenizer) to create your highly absorbable nutritional products. Most companies try to cut costs by using lower quality titanium probes, but that leads to titanium shedding which mixes with the solution compromises the purity. At NanoNSM, we only use the best quality tools to ensure your product is the purest.

High Pressure Homogenizer

Only work with GMP certified factories that use high-pressure homogenizers. We use a high-powered Microfluidizer (a High-Pressure Homogenizer) to create your highly absorbable nutraceuticals. At NanoNSM, we only use the best quality tools to ensure your product is the purest, most reliable, safest, effective, and potent.

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warning

Warning!

Not all Nano Micro-emulsions are created equal! We wrote an e-book on the 12 Questions to Ask Supplement Manufacturers BEFORE You Hire Them to make your Nano products.

Our Certifications