January 18, 2024
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Liposomes can enhance the absorption of water-soluble active substances
Oskar
According to several studies, liposomes can enhance the absorption of water-soluble active substances compared to when they are not encapsulated in liposomes. Liposomes, which mimic natural cell membranes, have been extensively studied as drug carriers due to their entrapment capacity, biocompatibility, and safety.
Research has shown that liposomal technology can improve the breakdown and absorption of both oil and water-soluble molecules in target cells. This enhancement in absorption is particularly beneficial for water-soluble compounds that may have lower bioavailability or face challenges in crossing biological barriers.
The incorporation of water-soluble active pharmaceutical ingredients (APIs) into liposomes has been found to increase their oral absorption. Studies have investigated the effect of liposomes on the absorption of water-soluble APIs, such as salbutamol sulfate and other pharmaceutical substances, and have reported positive results.
It is important to note that the effectiveness of liposomes in enhancing absorption may depend on various factors, including the specific active substance, liposome formulation, dosage form, and route of administration.
Sources:
- “Effect of liposomes on the absorption of water-soluble active pharmaceutical ingredients.” – PubMed
- “Adapting liposomes for oral drug delivery.” – ScienceDirect
- “The Benefits of Liposomes in Vitamins and Nutritional Molecules.” – Sequoia Lipo
- “Oral delivery of liposomes.” – Future Science
- “Nanocharacterization of liposomes for the encapsulation.” – Royal Society of Chemistry
PureNSM can create the above liposomes for water soluble actives like described above, however we would like the end product to be liquid. If you want to create liposomes with hydrophobic (oil soluble) ingredients, see below, then we can both deliver them in powder or liquid form. If you choose powder form then we recommend inclusion with cyclodextrin. Much like with liposomes, cyclodextrins prefer hydrophobic actives. What is very interesting is that once we have the cyclodextrin with the actives, we can then create an Extended-Slow-Release tablet.
We would recommend we mix both non-liposomal and liposomal actives with the cyclodextrin.
Liposomes created with oil-soluble actives are stronger and more robust than those created with water-soluble actives due to the nature of liposomes themselves. Liposomes are lipid-based vesicles composed of a phospholipid bilayer, which is essentially a double layer of fats. Since oil-soluble actives have a similar lipid structure, they can easily be incorporated into the lipid bilayer of liposomes without compromising the stability and integrity of the vesicles.
On the other hand, water-soluble actives do not readily integrate into the lipid bilayer of liposomes because of their hydrophilic (water-loving) nature. Incorporating water-soluble actives into liposomes often requires additional steps, such as altering the composition of the liposome formulation or using specialized techniques like thin-film hydration or reverse-phase evaporation.
By contrast, the lipophilic (fat-loving) nature of oil-soluble actives allows them to seamlessly integrate into the lipid bilayer of liposomes, resulting in a more straightforward encapsulation process. This compatibility simplifies the formulation process and enhances the stability and bioavailability of oil-soluble actives within liposomal delivery systems.
Sources:
- “Liposomes: A Review on Recent Cosmetic and Personal Care Applications” – Journal of Cosmetic Dermatology, 2020.
- “Liposomal Drug Delivery Systems: From Concepts to Clinical Applications” – International Journal of Pharmaceutics, 2017.
- “Liposomes: Technologies and Analytical Applications” – Annual Review of Analytical Chemistry, 2016.
Here is a list of hydrophobic supplements:
- Fat-Soluble Vitamins: Vitamins A, D, E, and K are considered hydrophobic or fat-soluble vitamins.
- Beta-carotene: Beta-carotene is a precursor to vitamin A and acts as a potent antioxidant. It is found in colorful fruits and vegetables like carrots, sweet potatoes, and spinach. Supplemental forms of beta-carotene are available for those who may have difficulty obtaining sufficient amounts from their diet.
- Omega-3 Fatty Acids: These essential fatty acids, including EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are found in fish oil supplements.
- Coenzyme Q10 (CoQ10): CoQ10 is a naturally occurring antioxidant that is found in high concentrations in organs with high energy requirements, such as the heart, liver, and kidneys.
- Curcumin: Curcumin is the active compound in turmeric, known for its anti-inflammatory and antioxidant properties.
- Resveratrol: Resveratrol is a polyphenol compound found in grapes, red wine, and certain berries, known for its potential health benefits.
- Astaxanthin: Astaxanthin is a carotenoid pigment found in certain marine plants and animals, known for its antioxidant and anti-inflammatory properties.
- Lutein and Zeaxanthin: These carotenoids are found in high amounts in green leafy vegetables and are beneficial for eye health.
- Vitamin E: Vitamin E is an antioxidant that helps protect cells from damage caused by free radicals.
- Saw Palmetto: Saw palmetto extract is commonly used as a dietary supplement for supporting prostate health in men.
- ScienceDirect: https://www.sciencedirect.com/science/article/pii/S0963996915302568
- LibreTexts: https://med.libretexts.org/Courses/Manchester_Community_College_(MCC)/Manchester_Community_College_-_Introduction_to_Nutrition/07%3A_Vitamins
- Other sources as cited in the search results.
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