Cyclodextrin Reaction Services

Cyclodextrin Reaction Services

We offer reaction services using our 25 gallon (94 Liters/kg) LEE Tri-Mix Turbo Shear Kettle and 24 tray oven capable of drying the batch received from the mixer.

Our service is ideal for those wanting increased absorption and prolonged absorption of metabolically important compounds, such as lipid-soluble vitamins, oil soluble supplements, such as CoQ10, curcumin, and hormones that have a very low solubility in aqueous solutions. Cyclodextrin as a “carrier” molecule that helps absorption and assimilation of desired compounds. Not only can this method increase absorption but it can also prolong the window of absorption.

Before the 1960 the solubility of natural cyclodextrins was very poor and prevented cyclodextrins from becoming effective complexing agents. It wasn’t until in the late 1960’s that chemists realized that by a chemical substitutions at the 2-, 3-, and 6-hydroxyl sites would greatly increase solubility.

Cyclodextrins are made of glucose linked together in a ring. This ring can be of different size, α-cyclodextrin with six, β-cyclodextrin with seven and γ-cyclodextrin with eight glucose units.

Cyclodextrins consist of multiple glucose building blocks linked together in a ring. Depending on the size of the ring, a distinction is made between α-cyclodextrin with six, β-cyclodextrin with seven and γ-cyclodextrin with eight glucose units.

The degree of chemical substitution and the nature of the groups used for substitution determine the final maximum concentration of cyclodextrin in an aqueous medium. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.

  • Product viscosities up to 2,000,000 CPS on primary double-motion
  • High hydraulic and mechanical shear
  • Clean, sanitary design
  • Particularly efficient for
  • hard-to-wet-out products
  • High-velocity axial and radial product flow
  • Continuous, high flow rate through the mixing head
  • Unique, double-motion agitator offset frame ensures uniform scraping action and
  • continuous product flow
  • Custom designs available
  • Batch-to-batch uniformity
  • Product scale-up and process guarantee
  • 316 stainless steel